BDBM18525 Bicalutamide::CHEMBL409::N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorobenzene)sulfonyl]-2-hydroxy-2-methylpropanamide::US11046713, Example Bicalutamide::US20230382870, Bicalutumide::US9126941, Bicalutamide::US9682960, CAS

SMILES CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=LKJPYSCBVHEWIU-UHFFFAOYSA-N

Data  25 KI  70 IC50  7 EC50

PDB links: 10 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18525   

TargetProgesterone receptor(Rattus norvegicus)
Astellas Pharma

LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataKi:  7.20E+3nMAssay Description:The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd] where [L] is the concentration of labeled ligand a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Oryctolagus cuniculus)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  5.60E+3nMAssay Description:Displacement of [3H]progesterone from rabbit PR by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Oryctolagus cuniculus)
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  5.60E+3nMAssay Description:Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  1.82E+3nMAssay Description:Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed